piRNA-mediated silencing protein C19orf84 (C19orf84)
Homo sapiens — UniProt I3L1E1
Data last refreshed: (UniProt release unknown)
Key facts
piRNA-mediated silencing protein C19orf84 (C19orf84) is a protein from Homo sapiens identified by UniProt accession I3L1E1, 186 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: I3L1E1; gene symbol C19orf84.
- Organism: Homo sapiens.
- Length: 186 amino acids.
- Top disease associations (Open Targets): neutrophil count, neutrophil percentage of leukocytes and sum of basophil and neutrophil counts.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | piRNA-mediated silencing protein C19orf84 |
|---|---|
| UniProt accession | I3L1E1 |
| Gene | C19orf84 |
| Organism | Homo sapiens |
| Length | 186 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.07
- neutrophil percentage of leukocytes · score 0.06
- sum of basophil and neutrophil counts · score 0.06
- granulocyte count · score 0.04
- lymphocyte percentage of leukocytes · score 0.04
- myeloid white cell count · score 0.04
- sum of neutrophil and eosinophil counts · score 0.04
- glaucoma · score 0.02
- brucellosis · score 0.00
- Crohn's disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-I3L1E1-F1 | alphafold | PREDICTED | 58.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for I3L1E1.
Amino-acid sequence (186 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with C19orf84?
The strongest Open Targets associations for C19orf84 are neutrophil count, neutrophil percentage of leukocytes, sum of basophil and neutrophil counts, granulocyte count and lymphocyte percentage of leukocytes.
How long is the C19orf84 protein?
The Homo sapiens C19orf84 protein (UniProt I3L1E1) is 186 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB I3L1E1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB I3L1E1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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