Small integral membrane protein 22 (SMIM22)
Homo sapiens — UniProt K7EJ46
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 22 (SMIM22) is a protein from Homo sapiens identified by UniProt accession K7EJ46, 83 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: K7EJ46; gene symbol SMIM22.
- Organism: Homo sapiens.
- Length: 83 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, skin aging and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 22 |
|---|---|
| UniProt accession | K7EJ46 |
| Gene | SMIM22 |
| Organism | Homo sapiens |
| Length | 83 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- skin aging · score 0.12
- body mass index · score 0.04
- mean corpuscular hemoglobin · score 0.04
- Barrett's esophagus · score 0.04
- C-C motif chemokine 3 measurement · score 0.03
- body height · score 0.03
- pulse pressure measurement · score 0.03
- body fat percentage · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-K7EJ46-F1 | alphafold | PREDICTED | 76.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for K7EJ46.
Amino-acid sequence (83 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM22?
The strongest Open Targets associations for SMIM22 are neurodegenerative disease, skin aging, body mass index, mean corpuscular hemoglobin and Barrett's esophagus.
How long is the SMIM22 protein?
The Homo sapiens SMIM22 protein (UniProt K7EJ46) is 83 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB K7EJ46 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB K7EJ46 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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