Sarcolipin (SLN)
Homo sapiens — UniProt O00631
Data last refreshed: (UniProt release unknown)
Key facts
Sarcolipin (SLN) is a protein from Homo sapiens identified by UniProt accession O00631, 31 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: O00631; gene symbol SLN.
- Organism: Homo sapiens.
- Length: 31 amino acids.
- Top disease associations (Open Targets): coronary artery disease, leukocyte count and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sarcolipin |
|---|---|
| UniProt accession | O00631 |
| Gene | SLN |
| Organism | Homo sapiens |
| Length | 31 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.22
- leukocyte count · score 0.08
- blood protein measurement · score 0.06
- PLIN1-related familial partial lipodystrophy · score 0.04
- CIDEC-related familial partial lipodystrophy · score 0.04
- Generalized congenital lipodystrophy with myopathy · score 0.04
- obesity due to melanocortin 4 receptor deficiency · score 0.04
- familial partial lipodystrophy, Dunnigan type · score 0.04
- PPARG-related familial partial lipodystrophy · score 0.04
- familial partial lipodystrophy, Kobberling type · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O00631-F1 | alphafold | PREDICTED | 91.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O00631.
Amino-acid sequence (31 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLN?
The strongest Open Targets associations for SLN are coronary artery disease, leukocyte count, blood protein measurement, PLIN1-related familial partial lipodystrophy and CIDEC-related familial partial lipodystrophy.
How long is the SLN protein?
The Homo sapiens SLN protein (UniProt O00631) is 31 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O00631 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O00631 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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