About Cocaine esterase
Cocaine esterase (CES2) is a protein
from Homo sapiens identified by UniProt accession
O00748, 559 residues long.
MolForge cross-references it against 0 known binders and
265 disease associations.
Target properties
| Protein name | Cocaine esterase |
|---|
| UniProt accession | O00748 |
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| Gene | CES2 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (265)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- urinary bladder cancer · score 0.11
- disseminated superficial actinic porokeratosis · score 0.10
- Non-epidermolytic palmoplantar keratoderma · score 0.09
- Blackfan-Diamond anemia · score 0.09
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.09
- keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome · score 0.09
- focal palmoplantar and gingival keratoderma · score 0.08
- punctate palmoplantar keratoderma type III · score 0.08
- Ichthyosis-hypotrichosis syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00748-F1 | alphafold | PREDICTED | 91.02 | — |
Amino-acid sequence (559 residues)
MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK ALPQKIQELE EPEERHTEL
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