Suppressor of cytokine signaling 2 (SOCS2)
Homo sapiens — UniProt O14508
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 2 (SOCS2) is a protein from Homo sapiens identified by UniProt accession O14508, 198 residues long. MolForge cross-references it against 0 known binders and 347 disease associations.
- UniProt accession: O14508; gene symbol SOCS2.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): body height, lean body mass and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 2 |
|---|---|
| UniProt accession | O14508 |
| Gene | SOCS2 |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (347)
Diseases linked to this target (Open Targets).
- body height · score 0.49
- lean body mass · score 0.48
- appendicular lean mass · score 0.43
- forced expiratory volume · score 0.42
- body weight · score 0.41
- sex hormone-binding globulin measurement · score 0.39
- fat body mass · score 0.39
- vital capacity · score 0.38
- IGF-1 measurement · score 0.33
- testosterone measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O14508-F1 | alphafold | PREDICTED | 82.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O14508.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS2?
The strongest Open Targets associations for SOCS2 are body height, lean body mass, appendicular lean mass, forced expiratory volume and body weight.
How long is the SOCS2 protein?
The Homo sapiens SOCS2 protein (UniProt O14508) is 198 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O14508 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O14508 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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