Suppressor of cytokine signaling 7 (SOCS7)
Homo sapiens — UniProt O14512
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 7 (SOCS7) is a protein from Homo sapiens identified by UniProt accession O14512, 581 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: O14512; gene symbol SOCS7.
- Organism: Homo sapiens.
- Length: 581 amino acids.
- Top disease associations (Open Targets): MODY, type 2 diabetes mellitus and type 1 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 7 |
|---|---|
| UniProt accession | O14512 |
| Gene | SOCS7 |
| Organism | Homo sapiens |
| Length | 581 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- MODY · score 0.10
- type 2 diabetes mellitus · score 0.08
- type 1 diabetes mellitus · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.06
- hyperinsulinism due to glucokinase deficiency · score 0.05
- Acanthosis nigricans - Insulin resistance - muscle cramps - acral enlargement · score 0.05
- acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome · score 0.05
- renal cysts and diabetes syndrome · score 0.04
- short stature due to partial GHR deficiency · score 0.04
- diabetic ketoacidosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O14512-F1 | alphafold | PREDICTED | 54.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O14512.
Amino-acid sequence (581 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS7?
The strongest Open Targets associations for SOCS7 are MODY, type 2 diabetes mellitus, type 1 diabetes mellitus, diabetes mellitus, transient neonatal, 2 and hyperinsulinism due to glucokinase deficiency.
How long is the SOCS7 protein?
The Homo sapiens SOCS7 protein (UniProt O14512) is 581 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O14512 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O14512 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.