Suppressor of cytokine signaling 3 (SOCS3)
Homo sapiens — UniProt O14543
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 3 (SOCS3) is a protein from Homo sapiens identified by UniProt accession O14543, 225 residues long. MolForge cross-references it against 0 known binders and 694 disease associations.
- UniProt accession: O14543; gene symbol SOCS3.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 3 |
|---|---|
| UniProt accession | O14543 |
| Gene | SOCS3 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (694)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- platelet count · score 0.31
- platelet crit · score 0.29
- C-reactive protein measurement · score 0.29
- creatine kinase measurement · score 0.22
- asthma · score 0.21
- osteoarthritis, hip · score 0.19
- respiratory system disease · score 0.19
- HbA1c measurement · score 0.19
- gastric adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O14543-F1 | alphafold | PREDICTED | 71.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O14543.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS3?
The strongest Open Targets associations for SOCS3 are neurodegenerative disease, platelet count, platelet crit, C-reactive protein measurement and creatine kinase measurement.
How long is the SOCS3 protein?
The Homo sapiens SOCS3 protein (UniProt O14543) is 225 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O14543 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O14543 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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