Suppressor of cytokine signaling 6 (SOCS6)
Homo sapiens — UniProt O14544
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 6 (SOCS6) is a protein from Homo sapiens identified by UniProt accession O14544, 535 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: O14544; gene symbol SOCS6.
- Organism: Homo sapiens.
- Length: 535 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, brain volume measurement and Inguinal hernia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 6 |
|---|---|
| UniProt accession | O14544 |
| Gene | SOCS6 |
| Organism | Homo sapiens |
| Length | 535 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- brain volume measurement · score 0.17
- Inguinal hernia · score 0.10
- non-small cell lung carcinoma · score 0.08
- breast cancer · score 0.04
- Kaposi's sarcoma · score 0.04
- gonorrhea · score 0.04
- neoplasm · score 0.04
- mean corpuscular volume · score 0.03
- mean corpuscular hemoglobin · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O14544-F1 | alphafold | PREDICTED | 53.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O14544.
Amino-acid sequence (535 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS6?
The strongest Open Targets associations for SOCS6 are neurodegenerative disease, brain volume measurement, Inguinal hernia, non-small cell lung carcinoma and breast cancer.
How long is the SOCS6 protein?
The Homo sapiens SOCS6 protein (UniProt O14544) is 535 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O14544 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O14544 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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