SMAD family member 7 (SMAD7)
Homo sapiens — UniProt O15105
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 7 (SMAD7) is a protein from Homo sapiens identified by UniProt accession O15105, 426 residues long. MolForge cross-references it against 0 known binders and 563 disease associations.
- UniProt accession: O15105; gene symbol SMAD7.
- Organism: Homo sapiens.
- Length: 426 amino acids.
- Top disease associations (Open Targets): colorectal cancer, mean corpuscular volume and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 7 |
|---|---|
| UniProt accession | O15105 |
| Gene | SMAD7 |
| Organism | Homo sapiens |
| Length | 426 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (563)
Diseases linked to this target (Open Targets).
- colorectal cancer · score 0.58
- mean corpuscular volume · score 0.52
- eosinophil count · score 0.51
- hemoglobin measurement · score 0.51
- erythrocyte count · score 0.51
- heel bone mineral density · score 0.50
- glomerular filtration rate · score 0.50
- hematocrit · score 0.50
- creatinine measurement · score 0.49
- mean corpuscular hemoglobin · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O15105-F1 | alphafold | PREDICTED | 73.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O15105.
Amino-acid sequence (426 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD7?
The strongest Open Targets associations for SMAD7 are colorectal cancer, mean corpuscular volume, eosinophil count, hemoglobin measurement and erythrocyte count.
How long is the SMAD7 protein?
The Homo sapiens SMAD7 protein (UniProt O15105) is 426 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O15105 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O15105 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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