SMAD family member 9 (SMAD9)
Homo sapiens — UniProt O15198
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 9 (SMAD9) is a protein from Homo sapiens identified by UniProt accession O15198, 467 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.
- UniProt accession: O15198; gene symbol SMAD9.
- Organism: Homo sapiens.
- Length: 467 amino acids.
- Top disease associations (Open Targets): pulmonary hypertension, primary, 2, heritable pulmonary arterial hypertension and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 9 |
|---|---|
| UniProt accession | O15198 |
| Gene | SMAD9 |
| Organism | Homo sapiens |
| Length | 467 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- pulmonary hypertension, primary, 2 · score 0.68
- heritable pulmonary arterial hypertension · score 0.56
- heel bone mineral density · score 0.47
- idiopathic pulmonary arterial hypertension · score 0.47
- pulmonary arterial hypertension · score 0.46
- colorectal cancer · score 0.38
- lung cancer · score 0.35
- body height · score 0.34
- hair colour measurement · score 0.31
- colorectal adenoma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O15198-F1 | alphafold | PREDICTED | 81.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O15198.
Amino-acid sequence (467 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD9?
The strongest Open Targets associations for SMAD9 are pulmonary hypertension, primary, 2, heritable pulmonary arterial hypertension, heel bone mineral density, idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension.
How long is the SMAD9 protein?
The Homo sapiens SMAD9 protein (UniProt O15198) is 467 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O15198 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O15198 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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