Suppressor of cytokine signaling 1 (SOCS1)
Homo sapiens — UniProt O15524
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 1 (SOCS1) is a protein from Homo sapiens identified by UniProt accession O15524, 211 residues long. MolForge cross-references it against 0 known binders and 890 disease associations.
- UniProt accession: O15524; gene symbol SOCS1.
- Organism: Homo sapiens.
- Length: 211 amino acids.
- Top disease associations (Open Targets): autoinflammatory syndrome with immunodeficiency, diffuse large B-cell lymphoma and lymphoid neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 1 |
|---|---|
| UniProt accession | O15524 |
| Gene | SOCS1 |
| Organism | Homo sapiens |
| Length | 211 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (890)
Diseases linked to this target (Open Targets).
- autoinflammatory syndrome with immunodeficiency · score 0.59
- diffuse large B-cell lymphoma · score 0.54
- lymphoid neoplasm · score 0.39
- common variable immunodeficiency · score 0.39
- Hodgkins lymphoma · score 0.37
- lymphoma · score 0.37
- non-functioning pituitary adenoma · score 0.37
- neoplasm of mature B-cells · score 0.37
- systemic lupus erythematosus · score 0.34
- Anemia, Hemolytic, Autoimmune · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O15524-F1 | alphafold | PREDICTED | 83.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O15524.
Amino-acid sequence (211 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS1?
The strongest Open Targets associations for SOCS1 are autoinflammatory syndrome with immunodeficiency, diffuse large B-cell lymphoma, lymphoid neoplasm, common variable immunodeficiency and Hodgkins lymphoma.
How long is the SOCS1 protein?
The Homo sapiens SOCS1 protein (UniProt O15524) is 211 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O15524 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O15524 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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