Cationic amino acid transporter 4 (SLC7A4)
Homo sapiens — UniProt O43246
Data last refreshed: (UniProt release unknown)
Key facts
Cationic amino acid transporter 4 (SLC7A4) is a protein from Homo sapiens identified by UniProt accession O43246, 635 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: O43246; gene symbol SLC7A4.
- Organism: Homo sapiens.
- Length: 635 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and Inguinal hernia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cationic amino acid transporter 4 |
|---|---|
| UniProt accession | O43246 |
| Gene | SLC7A4 |
| Organism | Homo sapiens |
| Length | 635 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- neuroinflammatory disorder · score 0.29
- Inguinal hernia · score 0.14
- adolescent idiopathic scoliosis · score 0.06
- central nervous system cancer · score 0.03
- glioblastoma multiforme · score 0.02
- 22q11.2 deletion syndrome · score 0.02
- cancer · score 0.02
- melanoma · score 0.01
- prostate adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O43246-F1 | alphafold | PREDICTED | 80.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O43246.
Amino-acid sequence (635 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC7A4?
The strongest Open Targets associations for SLC7A4 are neurodegenerative disease, neuroinflammatory disorder, Inguinal hernia, adolescent idiopathic scoliosis and central nervous system cancer.
How long is the SLC7A4 protein?
The Homo sapiens SLC7A4 protein (UniProt O43246) is 635 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O43246 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O43246 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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