Kunitz-type protease inhibitor 1 (SPINT1)
Homo sapiens — UniProt O43278
Data last refreshed: (UniProt release unknown)
Key facts
Kunitz-type protease inhibitor 1 (SPINT1) is a protein from Homo sapiens identified by UniProt accession O43278, 529 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: O43278; gene symbol SPINT1.
- Organism: Homo sapiens.
- Length: 529 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kunitz-type protease inhibitor 1 |
|---|---|
| UniProt accession | O43278 |
| Gene | SPINT1 |
| Organism | Homo sapiens |
| Length | 529 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- blood protein measurement · score 0.21
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.17
- cutaneous melanoma · score 0.14
- hepatocellular carcinoma · score 0.09
- esophageal squamous cell carcinoma · score 0.08
- neoplasm · score 0.06
- metabolite measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O43278-F1 | alphafold | PREDICTED | 76.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O43278.
Amino-acid sequence (529 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINT1?
The strongest Open Targets associations for SPINT1 are neurodegenerative disease, blood protein measurement, glioblastoma multiforme, breast adenocarcinoma and head and neck squamous cell carcinoma.
How long is the SPINT1 protein?
The Homo sapiens SPINT1 protein (UniProt O43278) is 529 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O43278 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O43278 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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