Kunitz-type protease inhibitor 2 (SPINT2)
Homo sapiens — UniProt O43291
Data last refreshed: (UniProt release unknown)
Key facts
Kunitz-type protease inhibitor 2 (SPINT2) is a protein from Homo sapiens identified by UniProt accession O43291, 252 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: O43291; gene symbol SPINT2.
- Organism: Homo sapiens.
- Length: 252 amino acids.
- Top disease associations (Open Targets): congenital sodium diarrhea, syndromic congenital sodium diarrhea and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kunitz-type protease inhibitor 2 |
|---|---|
| UniProt accession | O43291 |
| Gene | SPINT2 |
| Organism | Homo sapiens |
| Length | 252 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- congenital sodium diarrhea · score 0.65
- syndromic congenital sodium diarrhea · score 0.46
- platelet count · score 0.32
- serum alanine aminotransferase measurement · score 0.32
- prostate carcinoma · score 0.30
- platelet crit · score 0.27
- diverticular disease · score 0.24
- blood protein measurement · score 0.22
- male reproductive organ cancer · score 0.21
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O43291-F1 | alphafold | PREDICTED | 81.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O43291.
Amino-acid sequence (252 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINT2?
The strongest Open Targets associations for SPINT2 are congenital sodium diarrhea, syndromic congenital sodium diarrhea, platelet count, serum alanine aminotransferase measurement and prostate carcinoma.
How long is the SPINT2 protein?
The Homo sapiens SPINT2 protein (UniProt O43291) is 252 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O43291 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O43291 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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