SMAD family member 6 (SMAD6)
Homo sapiens — UniProt O43541
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 6 (SMAD6) is a protein from Homo sapiens identified by UniProt accession O43541, 496 residues long. MolForge cross-references it against 0 known binders and 313 disease associations.
- UniProt accession: O43541; gene symbol SMAD6.
- Organism: Homo sapiens.
- Length: 496 amino acids.
- Top disease associations (Open Targets): familial bicuspid aortic valve, congenital radioulnar synostosis and eye measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 6 |
|---|---|
| UniProt accession | O43541 |
| Gene | SMAD6 |
| Organism | Homo sapiens |
| Length | 496 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (313)
Diseases linked to this target (Open Targets).
- familial bicuspid aortic valve · score 0.66
- congenital radioulnar synostosis · score 0.64
- eye measurement · score 0.60
- body weights and measures · score 0.59
- hemoglobin measurement · score 0.56
- sitting height measurement · score 0.54
- erythrocyte count · score 0.52
- hematocrit · score 0.50
- aortic stenosis · score 0.48
- BMI-adjusted waist-hip ratio · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O43541-F1 | alphafold | PREDICTED | 70.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O43541.
Amino-acid sequence (496 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD6?
The strongest Open Targets associations for SMAD6 are familial bicuspid aortic valve, congenital radioulnar synostosis, eye measurement, body weights and measures and hemoglobin measurement.
How long is the SMAD6 protein?
The Homo sapiens SMAD6 protein (UniProt O43541) is 496 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O43541 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O43541 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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