Protein sprouty homolog 1 (SPRY1)
Homo sapiens — UniProt O43609
Data last refreshed: (UniProt release unknown)
Key facts
Protein sprouty homolog 1 (SPRY1) is a protein from Homo sapiens identified by UniProt accession O43609, 319 residues long. MolForge cross-references it against 0 known binders and 212 disease associations.
- UniProt accession: O43609; gene symbol SPRY1.
- Organism: Homo sapiens.
- Length: 319 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, heel bone mineral density and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein sprouty homolog 1 |
|---|---|
| UniProt accession | O43609 |
| Gene | SPRY1 |
| Organism | Homo sapiens |
| Length | 319 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (212)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- heel bone mineral density · score 0.37
- genetic disorder · score 0.27
- FEV/FVC ratio · score 0.23
- blood phosphate measurement · score 0.23
- platelet count · score 0.23
- hair shape measurement · score 0.23
- Alzheimer disease · score 0.22
- lysosomal storage disease · score 0.22
- Parkinson disease · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O43609-F1 | alphafold | PREDICTED | 62.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O43609.
Amino-acid sequence (319 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPRY1?
The strongest Open Targets associations for SPRY1 are neurodegenerative disease, heel bone mineral density, genetic disorder, FEV/FVC ratio and blood phosphate measurement.
How long is the SPRY1 protein?
The Homo sapiens SPRY1 protein (UniProt O43609) is 319 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O43609 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O43609 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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