Aldo-keto reductase family 1 member B10 (AKR1B10)

About Aldo-keto reductase family 1 member B10

Aldo-keto reductase family 1 member B10 (AKR1B10) is a protein from Homo sapiens identified by UniProt accession O60218, 316 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member B10
UniProt accession	O60218
Gene	AKR1B10
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (223)

Diseases linked to this target (Open Targets).

diastolic blood pressure · score 0.39
systolic blood pressure · score 0.39
Agents acting on the renin-angiotensin system use measurement · score 0.36
hypertension · score 0.36
cardiovascular disease · score 0.27
Calcium channel blocker use measurement · score 0.23
lung adenocarcinoma · score 0.23
white matter growth measurement · score 0.22
blood pressure · score 0.21
cutaneous melanoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60218-F1	alphafold	PREDICTED	97.74	—

Amino-acid sequence (316 residues)

MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFNAEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards