SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)
Homo sapiens — UniProt O60264
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) is a protein from Homo sapiens identified by UniProt accession O60264, 1052 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: O60264; gene symbol SMARCA5.
- Organism: Homo sapiens.
- Length: 1052 amino acids.
- Top disease associations (Open Targets): Failure to thrive, Hypotonia and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 |
|---|---|
| UniProt accession | O60264 |
| Gene | SMARCA5 |
| Organism | Homo sapiens |
| Length | 1052 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- Failure to thrive · score 0.55
- Hypotonia · score 0.55
- Intellectual disability · score 0.53
- Secondary microcephaly · score 0.46
- Short stature · score 0.40
- body height · score 0.36
- Microcephaly · score 0.34
- Global developmental delay · score 0.34
- Delayed CNS myelination · score 0.34
- flatfoot · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60264-F1 | alphafold | PREDICTED | 74.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60264.
Amino-acid sequence (1052 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCA5?
The strongest Open Targets associations for SMARCA5 are Failure to thrive, Hypotonia, Intellectual disability, Secondary microcephaly and Short stature.
How long is the SMARCA5 protein?
The Homo sapiens SMARCA5 protein (UniProt O60264) is 1052 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60264 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60264 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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