C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)
Homo sapiens — UniProt O60271
Data last refreshed: (UniProt release unknown)
Key facts
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) is a protein from Homo sapiens identified by UniProt accession O60271, 1321 residues long. MolForge cross-references it against 0 known binders and 220 disease associations.
- UniProt accession: O60271; gene symbol SPAG9.
- Organism: Homo sapiens.
- Length: 1321 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, heel bone mineral density and serum albumin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | C-Jun-amino-terminal kinase-interacting protein 4 |
|---|---|
| UniProt accession | O60271 |
| Gene | SPAG9 |
| Organism | Homo sapiens |
| Length | 1321 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (220)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- heel bone mineral density · score 0.38
- serum albumin measurement · score 0.32
- endometrial cancer · score 0.23
- bone quantitative ultrasound measurement · score 0.23
- hepatocellular carcinoma · score 0.16
- neoplasm · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- metabolite measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60271-F1 | alphafold | PREDICTED | 64.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60271.
Amino-acid sequence (1321 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAG9?
The strongest Open Targets associations for SPAG9 are neurodegenerative disease, heel bone mineral density, serum albumin measurement, endometrial cancer and bone quantitative ultrasound measurement.
How long is the SPAG9 protein?
The Homo sapiens SPAG9 protein (UniProt O60271) is 1321 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60271 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60271 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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