Sorting nexin-3 (SNX3)
Homo sapiens — UniProt O60493
Data last refreshed: (UniProt release unknown)
Key facts
Sorting nexin-3 (SNX3) is a protein from Homo sapiens identified by UniProt accession O60493, 162 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: O60493; gene symbol SNX3.
- Organism: Homo sapiens.
- Length: 162 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorting nexin-3 |
|---|---|
| UniProt accession | O60493 |
| Gene | SNX3 |
| Organism | Homo sapiens |
| Length | 162 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- Parkinson disease · score 0.46
- lysosomal storage disease · score 0.46
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- breast adenocarcinoma · score 0.23
- cardiomyopathy · score 0.07
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- microcytic anemia with liver iron overload · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60493-F1 | alphafold | PREDICTED | 88.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60493.
Amino-acid sequence (162 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNX3?
The strongest Open Targets associations for SNX3 are neurodegenerative disease, Parkinson disease, lysosomal storage disease, Alzheimer disease and multiple sclerosis.
How long is the SNX3 protein?
The Homo sapiens SNX3 protein (UniProt O60493) is 162 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60493 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60493 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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