Vinexin (SORBS3)
Homo sapiens — UniProt O60504
Data last refreshed: (UniProt release unknown)
Key facts
Vinexin (SORBS3) is a protein from Homo sapiens identified by UniProt accession O60504, 671 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: O60504; gene symbol SORBS3.
- Organism: Homo sapiens.
- Length: 671 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, breast adenocarcinoma and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vinexin |
|---|---|
| UniProt accession | O60504 |
| Gene | SORBS3 |
| Organism | Homo sapiens |
| Length | 671 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.20
- breast adenocarcinoma · score 0.18
- lymphocyte count · score 0.17
- risk-taking behaviour · score 0.12
- myeloid white cell count · score 0.08
- reticulocyte count · score 0.08
- reticulocyte measurement · score 0.06
- platelet count · score 0.04
- platelet crit · score 0.04
- Obesity · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60504-F1 | alphafold | PREDICTED | 56.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60504.
Amino-acid sequence (671 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORBS3?
The strongest Open Targets associations for SORBS3 are diastolic blood pressure, breast adenocarcinoma, lymphocyte count, risk-taking behaviour and myeloid white cell count.
How long is the SORBS3 protein?
The Homo sapiens SORBS3 protein (UniProt O60504) is 671 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60504 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60504 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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