Serine protease inhibitor Kazal-type 4 (SPINK4)
Homo sapiens — UniProt O60575
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 4 (SPINK4) is a protein from Homo sapiens identified by UniProt accession O60575, 86 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: O60575; gene symbol SPINK4.
- Organism: Homo sapiens.
- Length: 86 amino acids.
- Top disease associations (Open Targets): influenza A (H1N1), neurodegenerative disease and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 4 |
|---|---|
| UniProt accession | O60575 |
| Gene | SPINK4 |
| Organism | Homo sapiens |
| Length | 86 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- influenza A (H1N1) · score 0.32
- neurodegenerative disease · score 0.24
- adolescent idiopathic scoliosis · score 0.23
- Barrett's esophagus · score 0.08
- colitis · score 0.07
- glucose measurement · score 0.07
- electrocardiography · score 0.05
- inflammatory bowel disease · score 0.05
- neoplasm · score 0.04
- esophageal adenocarcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60575-F1 | alphafold | PREDICTED | 84.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60575.
Amino-acid sequence (86 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK4?
The strongest Open Targets associations for SPINK4 are influenza A (H1N1), neurodegenerative disease, adolescent idiopathic scoliosis, Barrett's esophagus and colitis.
How long is the SPINK4 protein?
The Homo sapiens SPINK4 protein (UniProt O60575) is 86 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60575 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60575 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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