Clathrin coat assembly protein AP180 (SNAP91)
Homo sapiens — UniProt O60641
Data last refreshed: (UniProt release unknown)
Key facts
Clathrin coat assembly protein AP180 (SNAP91) is a protein from Homo sapiens identified by UniProt accession O60641, 907 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: O60641; gene symbol SNAP91.
- Organism: Homo sapiens.
- Length: 907 amino acids.
- Top disease associations (Open Targets): schizophrenia, bipolar disorder and refractive error measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Clathrin coat assembly protein AP180 |
|---|---|
| UniProt accession | O60641 |
| Gene | SNAP91 |
| Organism | Homo sapiens |
| Length | 907 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.49
- bipolar disorder · score 0.44
- refractive error measurement · score 0.38
- age at menarche · score 0.38
- body height · score 0.37
- refractive error · score 0.33
- Abnormality of refraction · score 0.33
- cortical thickness · score 0.32
- unipolar depression · score 0.31
- obsessive-compulsive disorder · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60641-F1 | alphafold | PREDICTED | 53.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60641.
Amino-acid sequence (907 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNAP91?
The strongest Open Targets associations for SNAP91 are schizophrenia, bipolar disorder, refractive error measurement, age at menarche and body height.
How long is the SNAP91 protein?
The Homo sapiens SNAP91 protein (UniProt O60641) is 907 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60641 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60641 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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