Sorting nexin-2 (SNX2)
Homo sapiens — UniProt O60749
Data last refreshed: (UniProt release unknown)
Key facts
Sorting nexin-2 (SNX2) is a protein from Homo sapiens identified by UniProt accession O60749, 519 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: O60749; gene symbol SNX2.
- Organism: Homo sapiens.
- Length: 519 amino acids.
- Top disease associations (Open Targets): mean platelet volume, neutrophil count and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorting nexin-2 |
|---|---|
| UniProt accession | O60749 |
| Gene | SNX2 |
| Organism | Homo sapiens |
| Length | 519 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- neutrophil count · score 0.41
- platelet crit · score 0.37
- leukocyte count · score 0.34
- myeloid white cell count · score 0.33
- vital capacity · score 0.29
- platelet count · score 0.27
- neurodegenerative disease · score 0.23
- forced expiratory volume · score 0.14
- neuroimaging measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60749-F1 | alphafold | PREDICTED | 75.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60749.
Amino-acid sequence (519 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNX2?
The strongest Open Targets associations for SNX2 are mean platelet volume, neutrophil count, platelet crit, leukocyte count and myeloid white cell count.
How long is the SNX2 protein?
The Homo sapiens SNX2 protein (UniProt O60749) is 519 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60749 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60749 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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