Sphingomyelin phosphodiesterase 2 (SMPD2)
Homo sapiens — UniProt O60906
Data last refreshed: (UniProt release unknown)
Key facts
Sphingomyelin phosphodiesterase 2 (SMPD2) is a protein from Homo sapiens identified by UniProt accession O60906, 423 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: O60906; gene symbol SMPD2.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, thyroid gland adenocarcinoma and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingomyelin phosphodiesterase 2 |
|---|---|
| UniProt accession | O60906 |
| Gene | SMPD2 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.32
- thyroid gland adenocarcinoma · score 0.18
- body height · score 0.15
- lean body mass · score 0.13
- forced expiratory volume · score 0.11
- fat body mass · score 0.11
- hemoglobin measurement · score 0.11
- vital capacity · score 0.09
- appendicular lean mass · score 0.09
- peak expiratory flow · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O60906-F1 | alphafold | PREDICTED | 89.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O60906.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMPD2?
The strongest Open Targets associations for SMPD2 are Red cell distribution width, thyroid gland adenocarcinoma, body height, lean body mass and forced expiratory volume.
How long is the SMPD2 protein?
The Homo sapiens SMPD2 protein (UniProt O60906) is 423 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O60906 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O60906 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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