Plexin-A2 (PLXNA2)
Homo sapiens — UniProt O75051
Data last refreshed: (UniProt release unknown)
Key facts
Plexin-A2 (PLXNA2) is a protein from Homo sapiens identified by UniProt accession O75051, 1894 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.
- UniProt accession: O75051; gene symbol PLXNA2.
- Organism: Homo sapiens.
- Length: 1894 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, adolescent idiopathic scoliosis and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Plexin-A2 |
|---|---|
| UniProt accession | O75051 |
| Gene | PLXNA2 |
| Organism | Homo sapiens |
| Length | 1894 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (283)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- adolescent idiopathic scoliosis · score 0.38
- IGF-1 measurement · score 0.36
- cortical thickness · score 0.36
- cortical surface area measurement · score 0.36
- risk-taking behaviour · score 0.31
- insulin like growth factor measurement · score 0.30
- brain volume measurement · score 0.30
- brain measurement · score 0.29
- glucuronate measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75051-F1 | alphafold | PREDICTED | 84.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75051.
Amino-acid sequence (1894 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLXNA2?
The strongest Open Targets associations for PLXNA2 are neurodegenerative disease, adolescent idiopathic scoliosis, IGF-1 measurement, cortical thickness and cortical surface area measurement.
How long is the PLXNA2 protein?
The Homo sapiens PLXNA2 protein (UniProt O75051) is 1894 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75051 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75051 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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