Slit homolog 1 protein (SLIT1)
Homo sapiens — UniProt O75093
Data last refreshed: (UniProt release unknown)
Key facts
Slit homolog 1 protein (SLIT1) is a protein from Homo sapiens identified by UniProt accession O75093, 1534 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: O75093; gene symbol SLIT1.
- Organism: Homo sapiens.
- Length: 1534 amino acids.
- Top disease associations (Open Targets): protein measurement, neurodegenerative disease and Monomelic amyotrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Slit homolog 1 protein |
|---|---|
| UniProt accession | O75093 |
| Gene | SLIT1 |
| Organism | Homo sapiens |
| Length | 1534 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.31
- neurodegenerative disease · score 0.29
- Monomelic amyotrophy · score 0.26
- thyroid gland adenocarcinoma · score 0.18
- monocyte count · score 0.09
- body mass index · score 0.09
- neutrophil percentage of leukocytes · score 0.08
- glioblastoma · score 0.07
- neutrophil count · score 0.07
- leukocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75093-F1 | alphafold | PREDICTED | 79.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75093.
Amino-acid sequence (1534 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLIT1?
The strongest Open Targets associations for SLIT1 are protein measurement, neurodegenerative disease, Monomelic amyotrophy, thyroid gland adenocarcinoma and monocyte count.
How long is the SLIT1 protein?
The Homo sapiens SLIT1 protein (UniProt O75093) is 1534 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75093 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75093 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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