Slit homolog 3 protein (SLIT3)
Homo sapiens — UniProt O75094
Data last refreshed: (UniProt release unknown)
Key facts
Slit homolog 3 protein (SLIT3) is a protein from Homo sapiens identified by UniProt accession O75094, 1523 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: O75094; gene symbol SLIT3.
- Organism: Homo sapiens.
- Length: 1523 amino acids.
- Top disease associations (Open Targets): platelet count, body mass index and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Slit homolog 3 protein |
|---|---|
| UniProt accession | O75094 |
| Gene | SLIT3 |
| Organism | Homo sapiens |
| Length | 1523 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- platelet count · score 0.35
- body mass index · score 0.35
- PHF-tau measurement · score 0.34
- ulcerative colitis · score 0.32
- Alzheimer disease · score 0.31
- neurodegenerative disease · score 0.31
- lysosomal storage disease · score 0.31
- Parkinson disease · score 0.31
- multiple sclerosis · score 0.31
- age at menarche · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75094-F1 | alphafold | PREDICTED | 79.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75094.
Amino-acid sequence (1523 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLIT3?
The strongest Open Targets associations for SLIT3 are platelet count, body mass index, PHF-tau measurement, ulcerative colitis and Alzheimer disease.
How long is the SLIT3 protein?
The Homo sapiens SLIT3 protein (UniProt O75094) is 1523 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75094 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75094 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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