Suppressor of cytokine signaling 5 (SOCS5)
Homo sapiens — UniProt O75159
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of cytokine signaling 5 (SOCS5) is a protein from Homo sapiens identified by UniProt accession O75159, 536 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: O75159; gene symbol SOCS5.
- Organism: Homo sapiens.
- Length: 536 amino acids.
- Top disease associations (Open Targets): body mass index, body height and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of cytokine signaling 5 |
|---|---|
| UniProt accession | O75159 |
| Gene | SOCS5 |
| Organism | Homo sapiens |
| Length | 536 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- body mass index · score 0.47
- body height · score 0.45
- neurodegenerative disease · score 0.45
- hemoglobin measurement · score 0.40
- body fat percentage · score 0.39
- forced expiratory volume · score 0.39
- erythrocyte count · score 0.38
- BMI-adjusted waist circumference · score 0.37
- hematocrit · score 0.36
- appendicular lean mass · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75159-F1 | alphafold | PREDICTED | 61.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75159.
Amino-acid sequence (536 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOCS5?
The strongest Open Targets associations for SOCS5 are body mass index, body height, neurodegenerative disease, hemoglobin measurement and body fat percentage.
How long is the SOCS5 protein?
The Homo sapiens SOCS5 protein (UniProt O75159) is 536 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75159 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75159 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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