Small integral membrane protein 24 (SMIM24)
Homo sapiens — UniProt O75264
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 24 (SMIM24) is a protein from Homo sapiens identified by UniProt accession O75264, 130 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: O75264; gene symbol SMIM24.
- Organism: Homo sapiens.
- Length: 130 amino acids.
- Top disease associations (Open Targets): platelet count, skin aging and Barrett's esophagus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 24 |
|---|---|
| UniProt accession | O75264 |
| Gene | SMIM24 |
| Organism | Homo sapiens |
| Length | 130 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- platelet count · score 0.09
- skin aging · score 0.09
- Barrett's esophagus · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- reticulocyte count · score 0.09
- body height · score 0.08
- HbA1c measurement · score 0.07
- hepatocellular carcinoma · score 0.07
- platelet crit · score 0.06
- esophageal adenocarcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75264-F1 | alphafold | PREDICTED | 65.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75264.
Amino-acid sequence (130 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM24?
The strongest Open Targets associations for SMIM24 are platelet count, skin aging, Barrett's esophagus, high density lipoprotein cholesterol measurement and reticulocyte count.
How long is the SMIM24 protein?
The Homo sapiens SMIM24 protein (UniProt O75264) is 130 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75264 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75264 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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