Sperm-associated antigen 7 (SPAG7)
Homo sapiens — UniProt O75391
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated antigen 7 (SPAG7) is a protein from Homo sapiens identified by UniProt accession O75391, 227 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: O75391; gene symbol SPAG7.
- Organism: Homo sapiens.
- Length: 227 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated antigen 7 |
|---|---|
| UniProt accession | O75391 |
| Gene | SPAG7 |
| Organism | Homo sapiens |
| Length | 227 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- mean platelet volume · score 0.16
- serum metabolite measurement · score 0.15
- platelet count · score 0.13
- neutrophil count · score 0.12
- intraocular pressure measurement · score 0.07
- platelet component distribution width · score 0.07
- blood protein measurement · score 0.06
- platelet crit · score 0.05
- lean body mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75391-F1 | alphafold | PREDICTED | 85.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75391.
Amino-acid sequence (227 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAG7?
The strongest Open Targets associations for SPAG7 are neurodegenerative disease, mean platelet volume, serum metabolite measurement, platelet count and neutrophil count.
How long is the SPAG7 protein?
The Homo sapiens SPAG7 protein (UniProt O75391) is 227 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75391 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75391 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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