Sperm-associated antigen 6 (SPAG6)
Homo sapiens — UniProt O75602
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated antigen 6 (SPAG6) is a protein from Homo sapiens identified by UniProt accession O75602, 509 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.
- UniProt accession: O75602; gene symbol SPAG6.
- Organism: Homo sapiens.
- Length: 509 amino acids.
- Top disease associations (Open Targets): body height, protein measurement and fat body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated antigen 6 |
|---|---|
| UniProt accession | O75602 |
| Gene | SPAG6 |
| Organism | Homo sapiens |
| Length | 509 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (166)
Diseases linked to this target (Open Targets).
- body height · score 0.32
- protein measurement · score 0.31
- fat body mass · score 0.14
- neutrophil percentage of leukocytes · score 0.13
- lean body mass · score 0.13
- whole body water mass · score 0.13
- sitting height measurement · score 0.11
- base metabolic rate measurement · score 0.11
- B-cell acute lymphoblastic leukemia · score 0.09
- chronic myeloproliferative disorder · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75602-F1 | alphafold | PREDICTED | 95.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75602.
Amino-acid sequence (509 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAG6?
The strongest Open Targets associations for SPAG6 are body height, protein measurement, fat body mass, neutrophil percentage of leukocytes and lean body mass.
How long is the SPAG6 protein?
The Homo sapiens SPAG6 protein (UniProt O75602) is 509 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75602 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75602 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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