Sterol O-acyltransferase 2 (SOAT2)
Homo sapiens — UniProt O75908
Data last refreshed: (UniProt release unknown)
Key facts
Sterol O-acyltransferase 2 (SOAT2) is a protein from Homo sapiens identified by UniProt accession O75908, 522 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: O75908; gene symbol SOAT2.
- Organism: Homo sapiens.
- Length: 522 amino acids.
- Top disease associations (Open Targets): appendicular lean mass, cholesteryl ester measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sterol O-acyltransferase 2 |
|---|---|
| UniProt accession | O75908 |
| Gene | SOAT2 |
| Organism | Homo sapiens |
| Length | 522 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.26
- cholesteryl ester measurement · score 0.23
- high density lipoprotein cholesterol measurement · score 0.22
- sitting height measurement · score 0.22
- cutaneous melanoma · score 0.18
- lean body mass · score 0.11
- atherosclerosis · score 0.08
- coronary artery disease · score 0.08
- body height · score 0.06
- Hyperlipoproteinemia type 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75908-F1 | alphafold | PREDICTED | 82.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75908.
Amino-acid sequence (522 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOAT2?
The strongest Open Targets associations for SOAT2 are appendicular lean mass, cholesteryl ester measurement, high density lipoprotein cholesterol measurement, sitting height measurement and cutaneous melanoma.
How long is the SOAT2 protein?
The Homo sapiens SOAT2 protein (UniProt O75908) is 522 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75908 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75908 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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