Survival of motor neuron-related-splicing factor 30 (SMNDC1)
Homo sapiens — UniProt O75940
Data last refreshed: (UniProt release unknown)
Key facts
Survival of motor neuron-related-splicing factor 30 (SMNDC1) is a protein from Homo sapiens identified by UniProt accession O75940, 238 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: O75940; gene symbol SMNDC1.
- Organism: Homo sapiens.
- Length: 238 amino acids.
- Top disease associations (Open Targets): refractive error measurement, serum gamma-glutamyl transferase measurement and cardiovascular disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Survival of motor neuron-related-splicing factor 30 |
|---|---|
| UniProt accession | O75940 |
| Gene | SMNDC1 |
| Organism | Homo sapiens |
| Length | 238 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.27
- cardiovascular disease · score 0.22
- triglyceride measurement · score 0.21
- neurodegenerative disease · score 0.13
- mean corpuscular hemoglobin concentration · score 0.10
- mean corpuscular hemoglobin · score 0.09
- myeloid white cell count · score 0.07
- Crohn's disease · score 0.06
- birth weight · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O75940-F1 | alphafold | PREDICTED | 77.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O75940.
Amino-acid sequence (238 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMNDC1?
The strongest Open Targets associations for SMNDC1 are refractive error measurement, serum gamma-glutamyl transferase measurement, cardiovascular disease, triglyceride measurement and neurodegenerative disease.
How long is the SMNDC1 protein?
The Homo sapiens SMNDC1 protein (UniProt O75940) is 238 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O75940 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O75940 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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