Gamma-synuclein (SNCG)
Homo sapiens — UniProt O76070
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-synuclein (SNCG) is a protein from Homo sapiens identified by UniProt accession O76070, 127 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: O76070; gene symbol SNCG.
- Organism: Homo sapiens.
- Length: 127 amino acids.
- Top disease associations (Open Targets): body height, leukocyte count and esophageal squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-synuclein |
|---|---|
| UniProt accession | O76070 |
| Gene | SNCG |
| Organism | Homo sapiens |
| Length | 127 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- body height · score 0.08
- leukocyte count · score 0.07
- esophageal squamous cell carcinoma · score 0.04
- urate measurement · score 0.04
- bone density · score 0.04
- neoplasm · score 0.03
- central nervous system cancer · score 0.03
- heel bone mineral density · score 0.03
- cancer · score 0.03
- ovarian carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O76070-F1 | alphafold | PREDICTED | 76.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O76070.
Amino-acid sequence (127 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNCG?
The strongest Open Targets associations for SNCG are body height, leukocyte count, esophageal squamous cell carcinoma, urate measurement and bone density.
How long is the SNCG protein?
The Homo sapiens SNCG protein (UniProt O76070) is 127 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O76070 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O76070 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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