N(G),N(G)-dimethylarginine dimethylaminohydrolase 1…

About N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a protein from Homo sapiens identified by UniProt accession O94760, 285 residues long. MolForge cross-references it against 0 known binders and 277 disease associations.

Target properties

Protein name	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
UniProt accession	O94760
Gene	DDAH1
Organism	Homo sapiens
Length	285 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (277)

Diseases linked to this target (Open Targets).

body height · score 0.45
protein measurement · score 0.38
neurofibrillary tangles measurement · score 0.30
cortical surface area measurement · score 0.27
pulse pressure measurement · score 0.27
NG-monomethyl-arginine measurement · score 0.24
body mass index · score 0.22
urinary metabolite measurement · score 0.21
brain measurement · score 0.20
DNA methylation · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94760-F1	alphafold	PREDICTED	95.62	—

Amino-acid sequence (285 residues)

MAGLGHPAAF GRATHAVVRA LPESLGQHAL RSAKGEEVDV ARAERQHQLY VGVLGSKLGL QVVELPADES LPDCVFVEDV AVVCEETALI TRPGAPSRRK EVDMMKEALE KLQLNIVEMK DENATLDGGD VLFTGREFFV GLSKRTNQRG AEILADTFKD YAVSTVPVAD GLHLKSFCSM AGPNLIAIGS SESAQKALKI MQQMSDHRYD KLTVPDDIAA NCIYLNIPNK GHVLLHRTPE EYPESAKVYE KLKDHMLIPV SMSELEKVDG LLTCCSVLIN KKVDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)