Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
Homo sapiens — UniProt O94777
Data last refreshed: (UniProt release unknown)
Key facts
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) is a protein from Homo sapiens identified by UniProt accession O94777, 84 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: O94777; gene symbol DPM2.
- Organism: Homo sapiens.
- Length: 84 amino acids.
- Top disease associations (Open Targets): congenital muscular dystrophy with intellectual disability and severe epilepsy, congenital disorder of glycosylation and congenital disorder of glycosylation type I.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dolichol phosphate-mannose biosynthesis regulatory protein |
|---|---|
| UniProt accession | O94777 |
| Gene | DPM2 |
| Organism | Homo sapiens |
| Length | 84 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- congenital muscular dystrophy with intellectual disability and severe epilepsy · score 0.77
- congenital disorder of glycosylation · score 0.54
- congenital disorder of glycosylation type I · score 0.50
- serum urea measurement · score 0.23
- blood phosphate measurement · score 0.21
- creatinine measurement · score 0.16
- cataract · score 0.15
- monocyte count · score 0.08
- leukocyte count · score 0.07
- neutrophil count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O94777-F1 | alphafold | PREDICTED | 92.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O94777.
Amino-acid sequence (84 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPM2?
The strongest Open Targets associations for DPM2 are congenital muscular dystrophy with intellectual disability and severe epilepsy, congenital disorder of glycosylation, congenital disorder of glycosylation type I, serum urea measurement and blood phosphate measurement.
How long is the DPM2 protein?
The Homo sapiens DPM2 protein (UniProt O94777) is 84 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O94777 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O94777 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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