Sorbin and SH3 domain-containing protein 2 (SORBS2)
Homo sapiens — UniProt O94875
Data last refreshed: (UniProt release unknown)
Key facts
Sorbin and SH3 domain-containing protein 2 (SORBS2) is a protein from Homo sapiens identified by UniProt accession O94875, 1100 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.
- UniProt accession: O94875; gene symbol SORBS2.
- Organism: Homo sapiens.
- Length: 1100 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mathematical ability and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorbin and SH3 domain-containing protein 2 |
|---|---|
| UniProt accession | O94875 |
| Gene | SORBS2 |
| Organism | Homo sapiens |
| Length | 1100 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- mathematical ability · score 0.47
- body height · score 0.44
- self reported educational attainment · score 0.41
- coronary artery disease · score 0.29
- Varicose veins · score 0.28
- interleukin-6 measurement · score 0.24
- response to cytokine · score 0.24
- type 2 diabetes mellitus · score 0.23
- response to corticosteroid · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O94875-F1 | alphafold | PREDICTED | 52.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O94875.
Amino-acid sequence (1100 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORBS2?
The strongest Open Targets associations for SORBS2 are neurodegenerative disease, mathematical ability, body height, self reported educational attainment and coronary artery disease.
How long is the SORBS2 protein?
The Homo sapiens SORBS2 protein (UniProt O94875) is 1100 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O94875 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O94875 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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