Zinc finger protein 432 (ZNF432)
Homo sapiens — UniProt O94892
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 432 (ZNF432) is a protein from Homo sapiens identified by UniProt accession O94892, 652 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: O94892; gene symbol ZNF432.
- Organism: Homo sapiens.
- Length: 652 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, response to bronchodilator and response to corticosteroid.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 432 |
|---|---|
| UniProt accession | O94892 |
| Gene | ZNF432 |
| Organism | Homo sapiens |
| Length | 652 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- response to bronchodilator · score 0.26
- response to corticosteroid · score 0.26
- Shwachman-Diamond syndrome · score 0.03
- atypical hemolytic-uremic syndrome with C3 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with I factor anomaly · score 0.03
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly · score 0.03
- Blackfan-Diamond anemia · score 0.03
- tubulointerstitial kidney disease, autosomal dominant, 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O94892-F1 | alphafold | PREDICTED | 72.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O94892.
Amino-acid sequence (652 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF432?
The strongest Open Targets associations for ZNF432 are neurodegenerative disease, response to bronchodilator, response to corticosteroid, Shwachman-Diamond syndrome and atypical hemolytic-uremic syndrome with C3 anomaly.
How long is the ZNF432 protein?
The Homo sapiens ZNF432 protein (UniProt O94892) is 652 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O94892 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O94892 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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