Solute carrier organic anion transporter family member 2B1 (SLCO2B1)
Homo sapiens — UniProt O94956
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) is a protein from Homo sapiens identified by UniProt accession O94956, 709 residues long. MolForge cross-references it against 2 known binders and 79 disease associations.
- UniProt accession: O94956; gene symbol SLCO2B1.
- Organism: Homo sapiens.
- Length: 709 amino acids.
- Target class: Transporter.
- Approved drugs acting on it (DrugCentral): Erlotinib.
- Top disease associations (Open Targets): visual perception measurement, cutaneous melanoma and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier organic anion transporter family member 2B1 |
|---|---|
| UniProt accession | O94956 |
| Gene | SLCO2B1 |
| Organism | Homo sapiens |
| Length | 709 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (79)
Diseases linked to this target (Open Targets).
- visual perception measurement · score 0.26
- cutaneous melanoma · score 0.22
- neurodegenerative disease · score 0.17
- hepatocellular carcinoma · score 0.08
- neoplasm · score 0.08
- glioblastoma multiforme · score 0.02
- cancer · score 0.02
- lung carcinoma · score 0.02
- ulcerative colitis · score 0.01
- type 2 diabetes mellitus · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O94956-F1 | alphafold | PREDICTED | 78.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O94956.
Amino-acid sequence (709 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLCO2B1?
DrugCentral lists 1 approved drug whose mechanism of action is SLCO2B1: Erlotinib.
Which diseases are associated with SLCO2B1?
The strongest Open Targets associations for SLCO2B1 are visual perception measurement, cutaneous melanoma, neurodegenerative disease, hepatocellular carcinoma and neoplasm.
How long is the SLCO2B1 protein?
The Homo sapiens SLCO2B1 protein (UniProt O94956) is 709 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O94956 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O94956 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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