SLIT and NTRK-like protein 5 (SLITRK5)
Homo sapiens — UniProt O94991
Data last refreshed: (UniProt release unknown)
Key facts
SLIT and NTRK-like protein 5 (SLITRK5) is a protein from Homo sapiens identified by UniProt accession O94991, 958 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: O94991; gene symbol SLITRK5.
- Organism: Homo sapiens.
- Length: 958 amino acids.
- Top disease associations (Open Targets): autism spectrum disorder, Abnormal brain morphology and neuritic plaque measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SLIT and NTRK-like protein 5 |
|---|---|
| UniProt accession | O94991 |
| Gene | SLITRK5 |
| Organism | Homo sapiens |
| Length | 958 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- autism spectrum disorder · score 0.42
- Abnormal brain morphology · score 0.27
- neuritic plaque measurement · score 0.26
- obsessive-compulsive disorder · score 0.08
- trichodysplasia-xeroderma syndrome · score 0.04
- immunodeficiency 75 · score 0.03
- immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection · score 0.03
- Kimura disease · score 0.03
- trichotillomania · score 0.03
- Hepatic veno-occlusive disease - immunodeficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O94991-F1 | alphafold | PREDICTED | 65.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O94991.
Amino-acid sequence (958 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLITRK5?
The strongest Open Targets associations for SLITRK5 are autism spectrum disorder, Abnormal brain morphology, neuritic plaque measurement, obsessive-compulsive disorder and trichodysplasia-xeroderma syndrome.
How long is the SLITRK5 protein?
The Homo sapiens SLITRK5 protein (UniProt O94991) is 958 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O94991 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O94991 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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