Potassium channel subfamily K member 2 (KCNK2)

About Potassium channel subfamily K member 2

Potassium channel subfamily K member 2 (KCNK2) is a protein from Homo sapiens identified by UniProt accession O95069, 426 residues long. MolForge cross-references it against 0 known binders and 197 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 2
UniProt accession	O95069
Gene	KCNK2
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (197)

Diseases linked to this target (Open Targets).

delirium · score 0.56
Agitation · score 0.55
coronary artery disease · score 0.55
pain · score 0.54
ischemia reperfusion injury · score 0.54
kidney failure · score 0.53
acute respiratory distress syndrome · score 0.52
hypotension · score 0.50
post operative nausea and vomiting · score 0.50
COVID-19 · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95069-F1	alphafold	PREDICTED	76.10	—

Amino-acid sequence (426 residues)

MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL PAIIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS IKRKLSAELA GNHNQELTPC RRTLSVNHLT SERDVLPPLL KTESIYLNGL TPHCAGEEIA VIENIK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards