Desflurane

General Anesthetic — NERVOUS SYSTEM

Key facts

Desflurane is an ofp drug in the General Anesthetic class catalogued in DrugCentral. It was first approved by the FDA in 1992. DrugCentral lists 7 molecular targets, including KCNK2, KCNK3 and KCNK9. Recorded indications include General anesthesia.

• Approval status: ofp (first approved 1992 by the FDA).
• Drug class: General Anesthetic.
• Molecular targets: KCNK2, KCNK3, KCNK9 and KCNK10 (7 listed in DrugCentral).
• Indications: General anesthesia.
• ATC code: N01AB07 (Halogenated hydrocarbons).
• Molecular formula: C3H2F6O; molecular weight 168.04 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• General anesthesia

Contraindications (13)

• Benign intracranial hypertension
• Cirrhosis of liver
• Disease of liver
• Disorder of coronary artery
• Duchenne muscular dystrophy
• Familial periodic paralysis
• Hyperkalemia
• Lesion of brain
• Malignant hyperthermia
• Myasthenia gravis
• Neuromyopathy
• Viral hepatitis C
• Viral hepatitis type B

Mechanism & targets

• Established pharmacologic class: General Anesthetic

Molecular targets (7)

Target	Gene	Action	Activity
Potassium channel subfamily K member 2	KCNK2	opener	—
Potassium channel subfamily K member 3	KCNK3	opener	—
Potassium channel subfamily K member 9	KCNK9	opener	—
Potassium channel subfamily K member 10	KCNK10	opener	—
Potassium channel subfamily K member 18	KCNK18	opener	—
Glycine receptor (alpha-1/beta)	GLRA1|GLRB	other	—
GABA-A receptor; anion channel	GABRP|GABRD|GABRA1|GABRB1|GABRG2|GABRB3|GABRA5|GABRA3|GABRA2|GABRB2|GABRA4|GABRE|GABRA6|GABRG1|GABRG3|GABRQ	positive allosteric modulator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-09-18	FDA	—	BAXTER HLTHCARE

ATC classification

ATC code	Therapeutic hierarchy
N01AB07	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Halogenated hydrocarbons

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• EMA label
• FDA label: CACNA1S, RYR1 · Actionable PGx
• HCSC label: CACNA1S, RYR1 · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Hyperthermia malignant	292.0
Anaphylactic shock	245.8
Bradycardia	187.9
Serotonin syndrome	178.5
Neuromuscular block prolonged	140.5
Cardiac arrest	123.0
Bronchospasm	118.4
Delayed recovery from anaesthesia	107.1
Procedural hypotension	98.7
Vocal cord dysfunction	96.2
Post procedural complication	93.9
Drug interaction	93.1

Chemical structure

• Molecular formula: C₃H₂F₆O
• Molecular weight: 168.04 g/mol
• CAS number: —
• InChIKey: DPYMFVXJLLWWEU-UHFFFAOYSA-N
• PubChem CID: 42113

FC(F)OC(F)C(F)(F)F

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Desflurane used for?

DrugCentral lists the following indications for Desflurane: General anesthesia.

How does Desflurane work?

Its molecular targets in DrugCentral include KCNK2 (opener), KCNK3 (opener), KCNK9 (opener) and KCNK10 (opener).

When was Desflurane first approved?

Desflurane was first approved by the FDA in 1992.

What drug class does Desflurane belong to?

Desflurane is in the General Anesthetic class.

What is the chemical formula of Desflurane?

Desflurane has the molecular formula C3H2F6O and a molecular weight of 168.04 g/mol.

Sources

• DrugCentral drug card 811 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200733 — compound record and bioactivity
• PubChem CID 42113 — chemical identifiers
• DrugBank DB01189 — drug record
• FDA UNII CRS35BZ94Q — substance identity
• DailyMed: FDA labels for Desflurane — current prescribing information (label search)
• UniProt O95069 (KCNK2) — target protein
• UniProt O14649 (KCNK3) — target protein
• UniProt Q9NPC2 (KCNK9) — target protein
• UniProt P57789 (KCNK10) — target protein
• UniProt Q7Z418 (KCNK18) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.