About Potassium channel subfamily K member 10
Potassium channel subfamily K member 10 (KCNK10) is a protein
from Homo sapiens identified by UniProt accession
P57789, 538 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Potassium channel subfamily K member 10 |
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| UniProt accession | P57789 |
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| Gene | KCNK10 |
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| Organism | Homo sapiens |
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| Length | 538 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- delirium · score 0.56
- Agitation · score 0.55
- coronary artery disease · score 0.55
- pain · score 0.54
- ischemia reperfusion injury · score 0.54
- kidney failure · score 0.53
- acute respiratory distress syndrome · score 0.52
- post operative nausea and vomiting · score 0.50
- hypotension · score 0.50
- COVID-19 · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57789-F1 | alphafold | PREDICTED | 68.85 | — |
Amino-acid sequence (538 residues)
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
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