Enflurane

General Anesthetic — NERVOUS SYSTEM

Key facts

Enflurane is an ofm drug in the General Anesthetic class catalogued in DrugCentral. It was first approved by the FDA in 1972. DrugCentral lists 6 molecular targets, including GLRA1, KCNK2 and KCNK3. Recorded indications include General anesthesia.

• Approval status: ofm (first approved 1972 by the FDA).
• Drug class: General Anesthetic.
• Molecular targets: GLRA1, KCNK2, KCNK3 and KCNK9 (6 listed in DrugCentral).
• Indications: General anesthesia.
• ATC code: N01AB04 (Halogenated hydrocarbons).
• Molecular formula: C3H2ClF5O; molecular weight 184.49 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• General anesthesia

Contraindications (4)

• Duchenne muscular dystrophy
• Hyperkalemia
• Malignant hyperthermia
• Seizure disorder

Mechanism & targets

• Established pharmacologic class: General Anesthetic

Molecular targets (6)

Target	Gene	Action	Activity
Glycine receptor subunit alpha-1	GLRA1	other	—
Potassium channel subfamily K member 2	KCNK2	opener	—
Potassium channel subfamily K member 3	KCNK3	opener	—
Potassium channel subfamily K member 9	KCNK9	opener	—
Potassium channel subfamily K member 10	KCNK10	opener	—
Potassium channel subfamily K member 18	KCNK18	opener	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1972-08-28	FDA	—	BAXTER HLTHCARE

ATC classification

ATC code	Therapeutic hierarchy
N01AB04	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Halogenated hydrocarbons

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• EMA label

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Enflurane is on its molecule page.

• Molecular formula: C₃H₂ClF₅O
• Molecular weight: 184.49 g/mol
• CAS number: —
• InChIKey: JPGQOUSTVILISH-UHFFFAOYSA-N
• PubChem CID: 3226

FC(F)OC(F)(F)C(F)Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Enflurane used for?

DrugCentral lists the following indications for Enflurane: General anesthesia.

How does Enflurane work?

Its molecular targets in DrugCentral include GLRA1, KCNK2 (opener), KCNK3 (opener) and KCNK9 (opener).

When was Enflurane first approved?

Enflurane was first approved by the FDA in 1972.

What drug class does Enflurane belong to?

Enflurane is in the General Anesthetic class.

What is the chemical formula of Enflurane?

Enflurane has the molecular formula C3H2ClF5O and a molecular weight of 184.49 g/mol.

Sources

• DrugCentral drug card 1009 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1257 — compound record and bioactivity
• PubChem CID 3226 — chemical identifiers
• DrugBank DB00228 — drug record
• FDA UNII 91I69L5AY5 — substance identity
• DailyMed: FDA labels for Enflurane — current prescribing information (label search)
• UniProt P23415 (GLRA1) — target protein
• UniProt O95069 (KCNK2) — target protein
• UniProt O14649 (KCNK3) — target protein
• UniProt Q9NPC2 (KCNK9) — target protein
• UniProt P57789 (KCNK10) — target protein
• UniProt Q7Z418 (KCNK18) — target protein
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.