SAM pointed domain-containing Ets transcription factor (SPDEF)
Homo sapiens — UniProt O95238
Data last refreshed: (UniProt release unknown)
Key facts
SAM pointed domain-containing Ets transcription factor (SPDEF) is a protein from Homo sapiens identified by UniProt accession O95238, 335 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.
- UniProt accession: O95238; gene symbol SPDEF.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): monocyte count, prostate carcinoma and chronic lymphocytic leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SAM pointed domain-containing Ets transcription factor |
|---|---|
| UniProt accession | O95238 |
| Gene | SPDEF |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (184)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.33
- prostate carcinoma · score 0.32
- chronic lymphocytic leukemia · score 0.32
- progression free survival · score 0.31
- diffuse plaque measurement · score 0.28
- Red cell distribution width · score 0.23
- breast carcinoma · score 0.20
- total cholesterol measurement · score 0.15
- neoplasm · score 0.11
- breast cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O95238-F1 | alphafold | PREDICTED | 69.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O95238.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPDEF?
The strongest Open Targets associations for SPDEF are monocyte count, prostate carcinoma, chronic lymphocytic leukemia, progression free survival and diffuse plaque measurement.
How long is the SPDEF protein?
The Homo sapiens SPDEF protein (UniProt O95238) is 335 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O95238 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O95238 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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