Structural maintenance of chromosomes protein 2 (SMC2)
Homo sapiens — UniProt O95347
Data last refreshed: (UniProt release unknown)
Key facts
Structural maintenance of chromosomes protein 2 (SMC2) is a protein from Homo sapiens identified by UniProt accession O95347, 1197 residues long. MolForge cross-references it against 1 known binders and 93 disease associations.
- UniProt accession: O95347; gene symbol SMC2.
- Organism: Homo sapiens.
- Length: 1197 amino acids.
- Top disease associations (Open Targets): hemoglobin measurement, body height and non-melanoma skin carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structural maintenance of chromosomes protein 2 |
|---|---|
| UniProt accession | O95347 |
| Gene | SMC2 |
| Organism | Homo sapiens |
| Length | 1197 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.33
- body height · score 0.33
- non-melanoma skin carcinoma · score 0.32
- basal cell carcinoma · score 0.29
- cystatin C measurement · score 0.25
- skin neoplasm · score 0.24
- breast carcinoma · score 0.24
- keratinocyte carcinoma · score 0.24
- skin cancer · score 0.22
- glioblastoma multiforme · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-O95347-F1 | alphafold | PREDICTED | 83.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for O95347.
Amino-acid sequence (1197 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMC2?
The strongest Open Targets associations for SMC2 are hemoglobin measurement, body height, non-melanoma skin carcinoma, basal cell carcinoma and cystatin C measurement.
How long is the SMC2 protein?
The Homo sapiens SMC2 protein (UniProt O95347) is 1197 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB O95347 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB O95347 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.