Superoxide dismutase [Cu-Zn] (SOD1)
Homo sapiens — UniProt P00441
Data last refreshed: (UniProt release unknown)
Key facts
Superoxide dismutase [Cu-Zn] (SOD1) is a protein from Homo sapiens identified by UniProt accession P00441, 154 residues long. MolForge cross-references it against 1 known binders and 1,529 disease associations.
- UniProt accession: P00441; gene symbol SOD1.
- Organism: Homo sapiens.
- Length: 154 amino acids.
- Approved drugs acting on it (DrugCentral): Tofersen.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Superoxide dismutase [Cu-Zn] |
|---|---|
| UniProt accession | P00441 |
| Gene | SOD1 |
| Organism | Homo sapiens |
| Length | 154 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P00441-F1 | alphafold | PREDICTED | 97.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P00441.
Amino-acid sequence (154 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SOD1?
DrugCentral lists 1 approved drug whose mechanism of action is SOD1: Tofersen.
How long is the SOD1 protein?
The Homo sapiens SOD1 protein (UniProt P00441) is 154 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P00441 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P00441 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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