About Carbonic anhydrase 1
Carbonic anhydrase 1 (CA1) is a protein
from Homo sapiens identified by UniProt accession
P00915, 261 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | Carbonic anhydrase 1 |
|---|
| UniProt accession | P00915 |
|---|
| Gene | CA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (275)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.61
- glaucoma · score 0.60
- altitude sickness · score 0.60
- angle-closure glaucoma · score 0.59
- Seizure · score 0.59
- edema · score 0.59
- mean reticulocyte volume · score 0.57
- chronic obstructive pulmonary disease · score 0.57
- reticulocyte measurement · score 0.57
- heart failure · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00915-F1 | alphafold | PREDICTED | 96.83 | — |
Amino-acid sequence (261 residues)
MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSETK HDTSLKPISV SYNPATAKEI INVGHSFHVN FEDNDNRSVL KGGPFSDSYR LFQFHFHWGS TNEHGSEHTV DGVKYSAELH VAHWNSAKYS SLAEAASKAD GLAVIGVLMK VGEANPKLQK VLDALQAIKT KGKRAPFTNF DPSTLLPSSL DFWTYPGSLT HPPLYESVTW IICKESISVS SEQLAQFRSL LSNVEGDNAV PMQHNNRPTQ PLKGRTVRAS F
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