Serine protease inhibitor Kazal-type 1 (SPINK1)
Homo sapiens — UniProt P00995
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 1 (SPINK1) is a protein from Homo sapiens identified by UniProt accession P00995, 79 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.
- UniProt accession: P00995; gene symbol SPINK1.
- Organism: Homo sapiens.
- Length: 79 amino acids.
- Top disease associations (Open Targets): hereditary chronic pancreatitis, chronic pancreatitis and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 1 |
|---|---|
| UniProt accession | P00995 |
| Gene | SPINK1 |
| Organism | Homo sapiens |
| Length | 79 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (278)
Diseases linked to this target (Open Targets).
- hereditary chronic pancreatitis · score 0.77
- chronic pancreatitis · score 0.76
- blood protein measurement · score 0.39
- alcoholic pancreatitis · score 0.39
- diabetes mellitus · score 0.34
- acute pancreatitis · score 0.30
- hepatocellular carcinoma · score 0.12
- neoplasm · score 0.11
- pancreatitis · score 0.11
- cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P00995-F1 | alphafold | PREDICTED | 88.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P00995.
Amino-acid sequence (79 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK1?
The strongest Open Targets associations for SPINK1 are hereditary chronic pancreatitis, chronic pancreatitis, blood protein measurement, alcoholic pancreatitis and diabetes mellitus.
How long is the SPINK1 protein?
The Homo sapiens SPINK1 protein (UniProt P00995) is 79 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P00995 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P00995 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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